ABSTRACT
Objective To explore the high risk factors associated with severity of coronavirus disease-2019 (COVID-19) to provide a basis for precise diagnosis and treatment. Methods The clinical data of COVID-19 patients admitted to Fuyang Second People's Hospital in Anhui Province from Jan. 20, 2020 to Feb. 13, 2020 were retrospectively analyzed. According to the progress of the disease or not, the patients were divided into stable group and severe group. Multivariate COX proportional hazards regression analysis and dynamic changes were used to assess the high-risk factors for exacerbation of the disease. Results Finally 143 confirmed patients with COVID-19 were enrolled, the average age was 43.5(32.7, 52.4) years, 81(56.6%) cases were male, 28(19.6%) cases had at least one comorbidity (underlying disease). The most common symptom was fever (119, 83.2%), followed by dry cough (77, 53.8%). Totally, 122 patients (85.3%) had continued improvement(stable group), and 21(14.7%) deteriorated within 2 weeks of symptoms onset (severe group). Multivariate COX proportional hazards regression analysis showed that age over 60 years (HR=3.5, 95% CI 1.4-9.0), combined with underlying diseases (HR=3.9, 95% CI 1.5-10.4), LDH>250.0 U/L (HR=4.1, 95% CI 1.4-12.6), and absolute lymphocyte count less than 1.0×109/L (HR=6.8, 95% CI 2.3-20.7) were high risk factors for COVID-19 patient deterioration. Conclusions Identification of high-risk factors for deterioration of COVID-19 can assist early detection of cases with severe tendency and develop individualized and precise treatment strategy, which might alleviate the shortage of medical resources and reduce mortality.